The apparent recent mellowing of the sometimes vexed relationship between Sir Alex Ferguson and Arsène Wenger could well be tested in a potentially intriguing heavyweight FA Cup quarter-final against Arsenal at Old Trafford.
It all hinges on the outcome of Arsenal's ongoing fifth-round tie with Leyton Orient, with the winner drawn to face United.
Stoke City will be optimistic about reaching the semi-finals after being handed a home quarter-final against either West Ham or Burnley, who play their fifth-round tie at Upton Park on Monday night.
Clarke Carlisle suggests Tony Pulis's players should not be planning too far ahead however. Looking forward to meeting West Ham, the Burnley defender issued a reminder that his Championship side are resurgent under the new management of Eddie Howe.
"We are in good form at the moment, the squad is feeling confident," said Carlisle. "We have enough to cause any team in the land a problem. We're in with a fantastic shout."
Birmingham, already in the Carling Cup final, will host the winners of the currently ongoing fifth-round tie between Fulham and Bolton.
Roberto Mancini's trophy hungry Manchester City must overcome Aston Villa in the fifth round before meeting either Everton or Reading in what promises to be a fascinating quarter-final.
Sixth-round ties are scheduled to be played on the weekend of 12-13 March.
FA Cup sixth-round draw:
Stoke City v West Ham or Burnley
Man City or Aston Villa v Everton or Reading
Birmingham City v Bolton
Manchester United v Arsenal or Leyton Orient
Ties are to be played 12/13 March.