The Preston manager, Simon Grayson, and striker Jermaine Beckford have stunned Manchester United in the Cup once before, when their Leeds United team triumphed at Old Trafford in the third round five years ago. Beckford, the hero that day, is doubtful with an ear infection but Preston have regained momentum with three straight wins and are looking to become the second high-flying League One side to humiliate Louis van Gaal in domestic cup competition this season. Andy Hunter

Kick-off Monday 7.45pm

Odds H 7-1 A 1-2 D 15-4

Live BBC1

Referee Philip Dowd

Previous meetings Preston wins 22 Manchester Utd wins 31 Draws 22

Preston North End

Subs from Jones, Kilkenny, Keane, Buchanan, Reid, King, Holmes, Little, Robinson, Beckford, Ebanks-Blake

Doubtful Beckford (ear), Robinson (hamstring)

Injured Woods (hamstring, 21 Feb)

Cup-tied Johnson, Johnstone

Suspended None

Form DDLWWW

Discipline Y52 R1

Leading scorer Garner 14

Manchester United

Subs from Lindegaard, Valdés, Jones, Blackett, Valencia, Herrera, Januzaj, Da Silva, Young, Smalling, Fellaini, Van Persie, Thorpe

Doubtful Blind (head), Jones (shin), Van Persie (knock)

Injured Carrick (calf, 28 Feb)

Suspended None

Form WDWWDW

Discipline Y49 R4

Leading scorer Van Persie 10