Blackburn Rovers v Blackpool

Venue Ewood Park, Saturday 3pm

Referee Peter Bankes

Odds Blackburn Rovers 5-6 Blackpool 10-3 Draw 3-1

Head to head Blackburn Rovers wins 17 Blackpool wins 21 Draws 16

Two north-west sides with proud FA Cup histories, who may find the tie overshadowed by a joint protest from fans against their respective owners. For the hosts, six-time winners from 1884-1928, Championship survival is the more pressing concern, but Owen Coyle hopes to field a similar XI against the League Two side to that which drew with Birmingham last time out. For Gary Bowyer’s Seasiders, tales of 1953 will stir the appetite, as will his 11 years as a coach at Ewood Park. Stuart Goodwin

Match pointers:

• Blackburn let in five goals in their last home Cup game, as many as they had in their previous seven matches

• Blackpool have failed to keep a clean sheet in their last six Cup away games

Burnley v Bristol City

Venue Turf Moor, Saturday 3pm

Referee Andre Marriner

Odds Burnley 4-6 Bristol City 5-1 Draw 3-1

Head to head Burnley wins 17 Bristol City wins 16 Draws 15

Turf Moor has been a fortress this season for Burnley and as such the side have the fourth-best home record in the Premier League. Bristol City’s task is therefore all the more daunting especially when combined with their poor form of late in the Championship. After a promising start to the campaign Lee Johnson’s side sit two points above the relegation zone with a disastrous eight successive league defeats. The omens look great for Sean Dyche’s bid for the fifth round. Graham Searles

Match pointers:

• This is the 49th match between these sides but the first time they have met in the Cup

• Bristol City have not made it beyond the fourth round of the Cup since the 2000-01 season

Chelsea v Brentford

Venue Stamford Bridge, Saturday 3pm

Referee Michael Oliver

Odds Chelsea 1-5 Brentford 18-1 Draw 6-1

Head to head Chelsea wins 7 Brentford wins 4 Draws 2

Chelsea will face their former trainee Josh McEachran and when this sort of thing happens it tends to put the focus on their internal development and how difficult it has been to promote from their all-conquering youth teams. Perhaps Ruben Loftus-Cheek, Nathaniel Chalobah and Nathan Aké, all of whom will feature against Brentford, will change the picture. Chelsea are flying while Brentford have not made it into the fifth round since 2006. David Hytner

Match pointers:

• Chelsea have won 13 of their past 14 matches in all competitions

• The last time Brentford reached the fourth round – in 2012-13 – they went out to Chelsea after a replay

Fulham v Hull City

Venue Craven Cottage, Sunday 12.30pm

Referee Paul Tierney

Odds Fulham 11-10 Hull City 5-2 Draw 13-5

Head to head Fulham wins 29 Hull City wins 35 Draws 27

Fulham have already dispatched one Premier League side from a domestic cup competition this term and will be confident Hull City, now resigned to life without Robert Snodgrass, can be sent the same way as Middlesbrough back in the autumn. Slavisa Jokanovic picked a youthful side that night, though one would suspect Sone Aluko will have particular motivation to excel against his former club. The visitors won 1-0 in this fixture last season and will need to be as resilient as they were at Chelsea last Sunday if they are to progress. Dominic Fifield

Match pointers:

• Fulham have been eliminated at this stage in each of the past four seasons.

• Hull have not lost to a lower-league side in the Cup since Crawley knocked them out in 2011-12

Lincoln City v Brighton & Hove Albion

Venue Sincil Bank, Saturday 3pm

Referee Andrew Madley

Odds Lincoln City 4-1 Brighton & Hove Albion 4-5 Draw 3-1

Head to head Lincoln City wins 9 Brighton & Hove Albion wins 10 Draws 3

Lincoln provided the shock of the third round with their replay triumph over Ipswich, a result that will have the non-leaguers believing they can also unsettle the Championship leaders at Sincil Bank. Chris Hughton’s side have lost only once in their last 20 games, though, and while promotion to the Premier League is an obvious priority the man who won the Cup back-to-back with Tottenham in 1981 and 1982 will know not to underestimate the National League leaders. Paul Chronnell

Match pointers:

• Lincoln City are in the fourth round for the first time since Graham Taylor took them there in 1975-76

• Brighton have won their last eight Cup ties against non-league teams

Middlesbrough v Accrington Stanley

Venue Riverside Stadium, Saturday 3pm

Referee Anthony Taylor

Odds Middlesbrough 1-3 Accrington Stanley 9-1 Draw 4-1

Head to head Middlesbrough wins 0 Accrington Stanley wins 1 Draws 0

What mood might Middlesbrough fans be in after Aitor Karanka, contentiously, criticised them for encouraging long-ball football by chanting “attack, attack and attack,” and leaving games early? A tie against League Two Accrington Stanley offers a chance to appease a crowd who, rather than demanding direct football, would merely prefer Boro’s manager to be a little less cautious. They may be disappointed. “I don’t work eight hours a day to experiment in games,” Karanka said. “I don’t like experiments.” Louise Taylor

Match pointers:

• Middlesbrough have won nine of their past 10 Cup ties against sides from the fourth tier or lower

• Accrington Stanley have never progressed beyond the fourth round of the Cup

Oxford United v Newcastle United

Venue Kassam Stadium, Saturday 3pm

Referee David Coote

Odds Oxford United 4-1 Newcastle United 8-11 Draw 3-1

Head to head Oxford United wins 6 Newcastle United 6 Draws 5

Oxford United pulled off an upset knocking out Championship Rotherham in the previous round but will have to go one, or possibly three or four, better to knock out Newcastle. Rafael Benítez is an old hand at the FA Cup and will likely see the competition as a brilliant way to instil more confidence into his side to augment their push for promotion back into the top flight. Michael Appleton will be reminding his players of last year’s epic disposal of Swansea at the Kassam. Graham Searles

Match pointers:

• This is the first Cup game between these sides since May 1993, when they were both in the second tier

• Newcastle have not gone beyond the fourth round of the Cup since 2005-06

Rochdale v Huddersfield Town

Venue Crown Oil Arena, Saturday 3pm

Referee Oliver Langford

Odds Rochdale 5-2 Huddersfield Town 5-4 Draw 5-2

Head to head Rochdale wins 2 Huddersfield Town wins 12 Draws 10

Two sides with promotion aspirations could make for a captivating tie, with Huddersfield able to call on stories from their 1922 victory over Preston North End in the last Cup final before Wembley first opened. Keith Hill’s Rochdale, sixth in League One, go into the tie on the back of two defeats but hope to capitalise on injuries and absences that have befallen their Championship opponents, including Kasey Palmer, whose goal threat from midfield will be missed. Stuart Goodwin

Match pointers:

• Steve Davies has scored three times in his past three cup games after failing to score in his previous six

• Huddersfield have lost one of their past 12 games at Rochdale in all competitions

Tottenham Hotspur v Wycombe Wanderers

Venue White Hart Lane, Saturday 3pm

Referee Roger East

Odds Tottenham Hotspur 1-6 Wycombe Wanderers 20-1 Draw 9-1

Head to head n/a

Tuesday’s Premier League trip to Sunderland will dictate Mauricio Pochettino’s selection for this game but the Tottenham manager will have been made aware of Wycombe’s 16-match unbeaten run that dates back to early November and has elevated Gareth Ainsworth’s side to fifth place in League Two. They also have the threat of Adebayo ‘The Beast’ Akinfenwa, the much-travelled 16-stone striker who scored the late winner against Stourbridge in round three. Paul Chronnell

Match pointers:

• 24 of the last 26 teams to knock Tottenham out of the Cup have been from the top flight

• Wycombe’s only previous appearance at this stage was in 2000-01, when they went on to reach the semi-finals