Maro Itoje is set to miss England’s Six Nations matches against France and Wales and may be out for the rest of the tournament, because of knee ligament damage.

In better news for the head coach, Eddie Jones, Manu Tuilagi is clear to face France on Sunday after escaping a citing for a shoulder charge on Ireland’s Jacob Stockdale. Itoje’s absence, though, will be keenly felt.

England will confirm on Tuesday the length of Itoje’s injury but the best prognosis is thought to be a return for their last match of the championship, against Scotland on 16 March. England players have been known to make comebacks far quicker than expected but Itoje, who was on crutches during the celebrations after the win against Ireland on Saturday, may also have played his last Test before the World Cup in September.

Jones is well stocked at second row and Courtney Lawes made a considerable impact against Ireland off the bench, while Joe Launchbury is expected to come into the matchday squad in Itoje’s absence. It is nonetheless a blow for Jones to lose a player he believes “is going to become the best lock in the world”.

Itoje also sustained a knee injury towards the end of last year and spent five weeks out as a result. The initial injury was sustained at England’s October training camp in Portugal but he went on to play in all four of their autumn internationals and once for Saracens before the true extent of the problem became clear.

Tuilagi is free to play consecutive England matches for the first time in five years after the citing officer, Jeff Mark, chose not to bring disciplinary proceedings against the centre, thereby ending any possibility of a suspension. It is a boost for the England head coach considering the impact Tuilagi had in his first Six Nations start since 2013., not to mention the physical challenge posed by what Chris Ashton believes will be an “angry French team” following their capitulation against Wales.

“We’ve got a big Test against France – an angry France,” said Ashton, who scored 26 tries for Toulon last season. “They will be up for the game a little bit more now than they would have been had they got the win. We’ll be at home, which is in our favour, but it will be an angry French team, desperate to make up for the last 20 minutes of that game against Wales.

“A lot of their game is based on emotion but they’ve got a lot of good players, too. I’m sure there will be repercussions from that and that goes beyond emotion. They’ve got to get a win and make up for last week.

“If we know anything about the French, it’s that they love a reaction. They’ll definitely be putting everything into winning and they’ll have to in the situation they are in after losing at home. Their backs are against the wall and we expect nothing less.”

Elliot Daly will leave Wasps at the end of the season and the 26-year-old is widely expected to join Saracens. The full-back, who scored one of England’s four tries against Ireland in Dublin, has triggered a release clause in his contract and joins his Wasps teammate Christian Wade in announcing he is walking away from his boyhood club before his existing deal is up.