Whatever the true state of Wayne Rooney's ankle, Albion are likely to be without their own first-choice centre-forward as Peter Odemwingie is struggling to shake off a knee injury while Jerome Thomas is also doubtful. Theoretically, this should be straightforward for Manchester United, who have not dropped a league point at Old Trafford this season. Nevertheless, Roberto Di Matteo's first four away games have taken him to the old Big Four. They were first thrashed at Chelsea, pushed Liverpool hard and then shocked Arsenal. Tim Rich

Venue Old Trafford, Saturday 3pm

Tickets £27-49 (0161 868 8000)

Last season n/a

Referee M Jones

This season's matches 5 Y14, R1, 3.00 cards per game

Odds Manchester Utd 2-7 West Bromwich 12-1 Draw 5-1

Manchester Utd

Subs from Kuszczak, Brown, Gibson, Park, J Evans, Rafael, Obertan, Neville, Hernández, Smalling, Fábio, Owen, Anderson, Macheda, Bebé, Carrick

Doubtful Giggs (hamstring), Park (knee),

Injured Hargreaves (calf, 24 Oct), Valencia (broken leg, Mar)

Suspended None

Form guide DDWDWD

Disciplinary record Y14 R0

Leading scorer Berbatov 6

West Bromwich

Subs from Myhill, Thomas, Bednar, Tchoyi, Pablo, Barnes, Zuiverloon, Cox, Méïté, Reid, Miller, Odemwingie

Doubtful Odemwingie (knee), Thomas (calf)

Injured Cech (foot, 23 Oct), Mattock (thigh, 23 Oct)

Suspended None

Form guide DWWDLW

Disciplinary record Y12 R1

Leading scorer Odemwingie 3

Match pointers

• United have won 11 of their last 12 league meetings with Albion, scoring 34 goals and conceding only five times

• Albion's last win at Old Trafford in any competition came over 30 years ago in December 1978, when they triumphed 5-3

• United have scored three or more goals in 12 of their last 14 home top-flight matches

• Nani has provided the most assists (six) and had the most shots off-target (14) so far in the 2010-11 season

• If Albion lose it will be their 50th defeat away from home in the Premier League