The loss of Harry Kane is a blow for Tottenham and a huge boost for Manchester United. As Manchester City are five points ahead of United and Spurs, second and third respectively, a draw is surely undesirable and given the loss of Spurs’ star striker the onus is on José Mourinho’s men to go for the win. Considering Mourinho’s use of cat-and-mouse tactics it remains to be seen if he will instruct his side to do so. Jamie Jackson

Kick-off Saturday 12.30pm

Venue Old Trafford

Last season Man Utd 1 Tottenham 0

Live Sky Sports Premier League

Referee Jonathan Moss

This season G7, Y25, R1, 3.71 cards per game

Odds H 13-10 A 13-5 D 12-5

Manchester Utd

Subs from Pereira, Romero, Tuanzebe, Lindelof, Mata, Martial, McTominay, Rojo, Mitchell, Darmian, Blind, Shaw, Bailly

Doubtful Bailly (match fitness), Rojo (match fitness)

Injured Carrick (calf, 5 Nov), Fellaini (knee, 5 Nov), Pogba (hamstring, 18 Nov), Ibrahimovic (knee, Dec)

Suspended None

Form DWWWDL

Discipline Y13 R0

Leading scorer Lukaku 7

Tottenham Hotspur

Subs from Vorm, Gazzaniga, Aurier, Walker-Peters, Rose, Foyth, Sissoko, Dembélé, N’Koudou, Llorente

Doubtful None

Injured Kane (hamstring, 1 Nov), Lamela (hip, Nov), Wanyama (knee, unknown)

Suspended None

Form WDWWWW

Discipline Y12 R1

Leading scorer Kane 8